Lyme Disease Practice and Research

Research History

1. After a series of pilots over 5 years, a full scale Lyme disease Surveillance Database was successfully launched. Over two thousand patients with Lyme disease have been added consecutively to the Surveillance Database since the inception of the cohort in June 1997. History, signs, laboratory examinations, symptomology, and outcome data have been entered prospectively on every patient. The results were published in the peer review original article Consequences of treatment delay in Lyme disease. Click to learn more.

2. LymeProject initiated a clinical trial treating Lyme disease patients with recurrent Lyme disease with antibiotics to better understand the role of persistent infection and guide the development of innovative antibiotic treatment strategies. Pioneering design include: enrollment of patients using clinical judgment without serologic evidence, "proof-of-concept" using oral antibiotics, and launch from a primary care office. LDPR reported the feasibility of clinical trials for chronic Lyme disease. The results were published in the peer reviewed article Severity of Lyme disease with persistent symptoms.Click to learn more.

   Insights from a double-blind placebo-controlled clinical trial and follow-up letter Obstacles to trials of chronic Lyme disease in actual practice. Click to learn more.

3. Four peer reviewed analytic reviews titled, Generalizability in two clinical trials of Lyme disease, Severity of Lyme disease with persistent symptoms. Insights from a double-blind placebo-controlled clinical trial, Clinical trials validate the severity of persistent Lyme disease symptoms, and Insufficient evidence to deny antibiotic treatment to chronic Lyme disease patients.

4. First author of ILADS evidence based guideline. Click to learn more.

5. Review titled “Proof That Chronic Lyme Disease Exists”. Click to learn more.